Anesthesia and analgesia
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Anesthesia and analgesia · Jan 1993
Randomized Controlled Trial Clinical TrialIntravenous isoproterenol as a marker for epidural test-dosing in children.
The purpose of this study was to determine if isoproterenol would be an effective marker of intravascular injection in anesthetized children. Forty-four ASA 1 children, aged 2 mo to 10 yr, were randomly assigned to two groups. Children in group 1 (n = 21) received 0.05 microgram/kg isoproterenol, and children in group 2 (n = 23) received 0.075 microgram/kg isoproterenol. ⋯ Isoproterenol, 0.075 microgram/kg, is more sensitive but still is an imperfect marker of an intravascular injection. It produces a heart rate increase in 96% of children anesthetized with halothane and nitrous oxide in 50% oxygen. The application of isoproterenol as an epidural test dose appears promising, but cannot be recommended until its full reliability and neurotoxicity are evaluated.
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Anesthesia and analgesia · Jan 1993
Comparative StudyRecovery from pancuronium and vecuronium administered simultaneously in the isolated forearm and the effect on recovery following administration after cross-over of drugs.
If recovery of neuromuscular block in the isolated arm is determined by biophase binding, then a significant amount of drug will still be present in the biophase at 50% recovery of twitch response. To test this hypothesis we administered pancuronium at 50% recovery from vecuronium block and vecuronium at 50% recovery from pancuronium block in the isolated forearms of volunteers. ⋯ Prior administration of vecuronium significantly shortened the recovery from subsequent pancuronium when administered at 50% recovery, but not 100% recovery, and pancuronium significantly increased the recovery rate of vecuronium when given at 50% recovery but not 100% recovery. These findings support the concept of biophase binding of nondepolarizing neuromuscular blocking drugs.