Anesthesia and analgesia
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Anesthesia and analgesia · Feb 1996
Randomized Controlled Trial Clinical TrialTropisetron for the prevention of postoperative nausea and vomiting in women undergoing gynecologic surgery.
The aim of this study was to evaluate the efficacy of tropisetron, a selective 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, versus placebo in the prevention of postoperative nausea and vomiting in patients undergoing general anesthesia for gynecologic surgery. Ten minutes before induction of general anesthesia, 80 patients received in a double-blind manner a single intravenous (IV) injection of either 5 mg tropisetron or a matching placebo. Anesthesia was induced with thiopental and maintained with nitrous oxide and enflurane in oxygen. ⋯ The incidence of nausea was 30% (12/40) in the tropisetron group and 52% (21/40) in the placebo group (P < 0.05). A total effective antiemetic response showed 26 patients (65%) in the tropisetron group and 16 patients (40%) in the placebo group (P < 0.05). We conclude that tropisetron given IV prior to gynecologic procedures in general anesthesia significantly reduces postoperative nausea and vomiting when compared to placebo without causing any adverse effect.
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Anesthesia and analgesia · Feb 1996
Randomized Controlled Trial Comparative Study Clinical TrialContinuous hypopharyngeal pH measurements in spontaneously breathing anesthetized outpatients: laryngeal mask airway versus tracheal intubation.
We measured the hypopharyngeal pH to compare the incidence of regurgitation associated with the laryngeal mask airway (LMA) and the tracheal tube (TT) in spontaneously breathing, anesthetized patients. Sixty outpatients scheduled for elective peripheral surgery with a standardized general anesthetic technique were randomly allocated to receive either a LMA (n = 28) or a TT (n = 32) for airway management. A 4-mm pH electrode was placed in the hypopharynx, and pH values were continuously collected and stored in a portable pH data logger system until the end of the operation. ⋯ The hypopharyngeal pH values in both groups were similar, ranging between 5.5 and 7.5, with median values of 5.7 and 6.2 in the LMA and TT groups, respectively. The pH in any given patient did not vary more than 1.0 unit from the initial value recorded at the start of the operation. We conclude that continuous monitoring of the hypopharyngeal pH in spontaneously breathing, anesthetized outpatients failed to detect evidence of pharyngeal regurgitation.
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Anesthesia and analgesia · Feb 1996
Randomized Controlled Trial Clinical TrialOral clonidine premedication reduces postoperative pain in children.
Clonidine is an effective preanesthetic medication in children, providing a preoperative sedative effect. The analgesic properties of the drug have been well documented in adults. The current study was designed to investigate the effect of oral clonidine given preoperatively on postoperative pain in children undergoing minor surgery. ⋯ Postoperative pain was assessed by a blinded observer using an objective pain scale (OPS). Clonidine 4 micrograms/kg provided lower OPS (highest) scores during 12 h after surgery and reduced requirement for postoperative supplementary analgesic (diclofenac suppository) compared with the other two regimens. These data suggest that oral clonidine premedication (4 micrograms/kg) is a possible approach to facilitating postoperative analgesia in children undergoing minor surgery.