Anesthesia and analgesia
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Anesthesia and analgesia · Aug 1997
Does the platelet-activated clotting test (HemoSTATUS) predict blood loss and platelet dysfunction associated with cardiopulmonary bypass?
Platelet dysfunction is a major cause of bleeding after cardiopulmonary bypass (CPB). No timely, simple, point-of-care determinant of platelet function is available for clinical use. Adding platelet-activating factor to conventional activated clotting time methods (platelet-activated clotting test [PACT]) (HemoSTATUS; Medtronic, Inc., Parker, CO) produces rapid results (<3 min) and may yield a measure of platelet responsiveness and whole blood procoagulant activity. ⋯ The PACT had a sensitivity and specificity comparable to routine laboratory coagulation tests in predicting blood loss. The TEG maximum amplitude, however, was more predictive than both the PACT and routine coagulation tests in this respect. The PACT may be a useful indicator of platelet responsiveness or whole blood procoagulant activity, but we did not find it superior to other tests of coagulation function for predicting excessive blood loss after CPB.
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Detection of the intravascular placement of epidural catheters is an important but difficult task. In this study, we evaluated maternal and fetal hemodynamic responses to intravenous (i.v.) and epidural injection of isoproterenol (ISO), a proposed chronotropic test dose, in gravid ewes. Near-term, chronically instrumented, gravid ewes with single fetuses were studied at least 48 h after surgery. ⋯ However, ISO seems to be rapidly absorbed from the epidural space. Identifying the source of maternal tachycardia after epidural injection of a large dose of ISO could be difficult. If the absence of histopathological change is confirmed, ISO represents an alternative to EPI as a chronotropic test dose.
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Anesthesia and analgesia · Aug 1997
Safe epidural analgesia in thirty parturients with platelet counts between 69,000 and 98,000 mm(-3).
Regional anesthesia is a popular form of pain relief for the management of labor and delivery. Thrombocytopenia is considered a relative contraindication to the administration of regional anesthesia. Some authorities have recommended that an epidural anesthetic be withheld if the platelet count is <100,000 mm(-3). ⋯ Of these 80, 30 had an epidural anesthetic placed when the platelet count was <100,000 mm(-3) (range 69,000-98,000 mm(-3)), 22 had an epidural anesthetic placed with a platelet count >100,000 mm(-3) that subsequently decreased below 100,000 mm(-3), and 28 did not receive a regional anesthetic. We found no documentation of any neurologic complications in the medical records. We conclude that regional anesthesia should not necessarily be withheld when the platelet count is <100,000 mm(-3).
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Anesthesia and analgesia · Aug 1997
Biography Historical ArticleAnesthesia & Analgesia: seventy-five years of publication.