Anesthesia and analgesia
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Anesthesia and analgesia · Apr 2002
Calibrated pneumoperitoneal venting to prevent N2O accumulation in the CO2 pneumoperitoneum during laparoscopy with inhaled anesthesia: an experimental study in pigs.
Nitrous oxide (N2O) accumulates in the CO2 pneumoperitoneum during laparoscopy when N2O is used as an adjuvant for inhaled anesthesia. This may worsen the consequences of gas embolism and introduce a fire risk. In this study, we quantified the pneumoperitoneal gas venting necessary to prevent significant contamination by inhaled N2O. Four domestic pigs (26-30 kg) were anesthetized and ventilated with 66% N2O in oxygen. A CO2 pneumoperitoneum was insufflated and maintained at a pressure of 12 mm Hg. Each animal underwent three experimental conditions, in random sequence, for 70 min each: 1) no pneumoperitoneal leak, 2) leak of 2 L every 10 min (12 L/h), and 3) leak of 4 L every 10 min (24 L/h). Every 10 min, pneumoperitoneal gas samples were analyzed for fractions (FPn) of N2O and CO2. Without leaks, FPnN2O increased continually and reached 29.58% +/- 3.15% at 70 min. With leaks of 2 and 4 L every 10 min (12 and 24 L/h), FPnN2O reached a plateau of <10% after 30 min. We conclude that calibrated pneumoperitoneal venting of 12 or 24 L/h is enough to prevent the constitution of potentially dangerous pneumoperitoneal gas mixtures if venting is constant. ⋯ External venting calibrated at four or eight initial pneumoperitoneal volumes per hour with compensation by fresh CO2 is sufficient to prevent nitrous oxide buildup of more than 10% in the pneumoperitoneum during laparoscopy with inhaled general anesthesia if venting is constant.
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Anesthesia and analgesia · Apr 2002
Neuromuscular pharmacology of TAAC3, a new nondepolarizing muscle relaxant with rapid onset and ultrashort duration of action.
We selected bis [N-(3,4-diacetoxybenzyl) tropanium-3alpha-yl] glutarate dibromide (TAAC3) from many new tropinyl diester derivatives to evaluate its neuromuscular blocking (NMB) and autonomic side effects on anesthetized rats, rabbits, guinea pigs, cats, pigs, dogs, and monkeys. NMB potency, onset, recovery index, and duration of action were determined. Comparisons of these pharmacologic variables were made between TAAC3 and rocuronium. In the cat, the degrees of train-of-four and tetanic fade, posttetanic potentiation, and pharmacologic antagonism were evaluated. For determination of the NMB maintenance dose, TAAC3 was also given to rabbits and pigs in the initial dose/maintenance infusion mode. Cardiac vagal block was evaluated in the rat, pig, cat, and guinea pig on the basis of the inhibition of the bradycardia to stimulation of the vagus nerve. Sympathetic ganglion block was studied on the superior cervical ganglion-nictitating membrane preparation of the cat. TAAC3 produced nondepolarizing NMB. Its NMB 90% effective doses ranged from 90 to 425 microg/kg, depending on the species. TAAC3 had a faster onset (0.8-1.0 min), shorter recovery index (0.6-1.1 min), and shorter duration of action (1.8-3.5 min) than rocuronium. It produced a slight cumulative effect on infusion, but not on repeated single-dose administration. Cardiac vagal block was present at doses exceeding the NMB 90% effective dose. In the cat and pig at equipotent NMB doses, the degree of cardiac vagal block was similar to that of rocuronium. There was no demonstrable sympathetic ganglion block in the cat. In view of its favorable NMB characteristics, TAAC3 is now undergoing detailed preclinical studies. ⋯ We developed a new nondepolarizing muscle relaxant, TAAC3, and investigated it in several animal models. TAAC3 has shown a very rapid onset and an ultrashort duration of neuromuscular blocking action. A minor degree of cardiac vagal block was observed. TAAC3 is promising for further studies.
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Anesthesia and analgesia · Apr 2002
Case ReportsPossible bupivacaine toxicity after intraarticular injection for postarthroscopic analgesia of the knee: implications of the surgical procedure.
We report a case of possible bupivacaine toxicity after intraarticular injection during knee arthroscopy. The importance of the specific type of surgical procedure performed during arthroscopy and its relationship to potential local anesthetic toxicity are highlighted.
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Anesthesia and analgesia · Apr 2002
The feasibility of transesophageal echocardiograph-guided right and left ventricular oximetry in hemodynamically stable patients undergoing coronary artery bypass grafting.
There are no techniques available for continuous noninvasive measurement of the oxygen saturation of blood flowing through the heart. We assessed the feasibility and accuracy of transesophageal echocardiograph (TEE)-guided left ventricular (SpO2 LV) and right ventricular (SpO2 RV) oximetry. Twenty hemodynamically stable, well-oxygenated anesthetized patients (ASA physical status III, aged 51-75 yr) undergoing coronary artery bypass grafting were studied. A TEE probe was modified by attaching a single-use pediatric reflectance pulse oximeter just proximal to the ultrasound transducer. The TEE probe was directed toward the LV by using the transgastric mid-short axis view or toward the RV by using the transgastric RV inflow view, in random order. Readings were taken every 30 s for 10 min during a hemodynamically stable period of anesthesia. Simultaneous blood samples were taken from the radial artery and pulmonary artery to determine arterial oxygen saturation (SaO2) and mixed venous oxygen saturation (SvO2), respectively. During SpO2 LV readings, simultaneous finger pulse oximetry (SpO2 finger) was also recorded. SpO2 LV was feasible in 20 of 20 patients, and SpO2 RV was feasible in 19 of 20 patients. The mean +/- SD (range) oxygen saturation for each method was the following: SpO2 LV, 98.7% +/- 0.6% (97%-100%); SaO2, 98.7% +/- 0.6% (96.6%-99.4%); SpO2 finger, 98.1% +/- 1.2% (97%-100%); SpO2 RV, 73.9% +/- 4.7% (64%-85%); and SvO2, 74.5% +/- 4.4% (66.8%-82.6%). SpO2 LV agreed closely with SaO2 (mean difference, 0.072%). SpO2 RV agreed closely with SvO2 (mean difference, 0.65%). SpO2 LV agreed more closely with SaO2 than finger oximetry (mean difference, -0.072 vs -0.692). TEE-guided SpO2 LV and SpO2 RV are feasible in hemodynamically stable anesthetized patients and provide similar readings to arterial and mixed venous blood samples. The technique merits further investigation. ⋯ Transesophageal echocardiograph-guided left and right ventricular oximetry is feasible in hemodynamically stable anesthetized patients and provides similar readings to arterial and mixed venous blood samples.
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Anesthesia and analgesia · Apr 2002
Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury.
Local thermal injury to the paw leads to an increased sensitivity to a noxious stimulus applied to the site (primary thermal hyperalgesia) and an increased sensitivity to tactile stimuli in skin sites adjacent to the primary injury (secondary tactile allodynia; 2 degrees TA). We sought to define the peripheral and spinal actions of mu opioids in regulating 2 degrees TA. First, a mild thermal injury was induced on one heel, producing 2 degrees TA. This 2 degrees TA was blocked by pretreatment, but not posttreatment, with a topical mu-opioid agonist, loperamide (1.7%-5%). Second, 2 degrees TA was blocked by intrathecal morphine (0.1-10 microg) pre- and postinjury. 2 degrees TA reappeared when systemic naloxone was given before, but not after, injury in intrathecal morphine-pretreated rats. Intrathecal remifentanil, a short-lasting mu-opioid agonist, infused periinjury (3 microg/min), did not block subsequent primary thermal hyperalgesia, but it produced a dose-dependent (0.3-3 microg/min) abolition of 2 degrees TA. Local tissue injury leads to 2 degrees TA by the activation of opiate-sensitive afferents and the initiation of a cascade that persists in the absence of that initiating injury-induced stimulus. ⋯ Sensitivity to touch observed in areas adjacent to injury is blocked by opioids applied before, but not after, injury. This suggests that injury-activated opioid-sensitive fibers are responsible for sensitization and reveals a cascade that is diminished by pretreatment but not posttreatment, providing a rationale for adequate analgesia before injury (surgery) has occurred.