Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2004
Randomized Controlled Trial Clinical TrialThe effects of cisatracurium on morbidly obese women.
There is conflicting evidence on the duration of action of atracurium in obese patients. Cisatracurium is one of the stereoisomers of atracurium. We investigated the neuromuscular effects of cisatracurium in morbidly obese patients. ⋯ The duration 25% was longer in Group I than in the control group (74.6 min versus 59.1 min; P = 0.01) and in the control group compared with Group II (45.0 min; P = 0.016). In conclusion, the duration of action of cisatracurium was prolonged in morbidly obese patients when dosed according to RBW compared with a control group of normal weight patients. Duration was also prolonged in the control group patients compared with morbidly obese patients to whom the drug was administered on the basis of IBW.
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Anesthesia and analgesia · Oct 2004
Randomized Controlled Trial Clinical TrialSmall-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response study.
We examined the dose-response relationship of intrathecal clonidine at small doses (
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Anesthesia and analgesia · Oct 2004
Randomized Controlled Trial Clinical TrialPropofol does not inhibit lidocaine metabolism during epidural anesthesia.
Propofol is sometimes used in combination with epidural anesthesia with lidocaine. In this study, we investigated the effect of propofol on the plasma concentration of lidocaine and its principal metabolites during epidural anesthesia with lidocaine. Thirty-two patients were randomly allocated to receive either propofol or sevoflurane anesthesia (n = 16 each). ⋯ The plasma concentrations of free lidocaine were not significantly different between groups. The ratios of free MEGX to free lidocaine and free GX to free MEGX were not different between groups. In conclusion, propofol does not alter the metabolism of epidural lidocaine compared with sevoflurane.
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Anesthesia and analgesia · Oct 2004
Case ReportsPeripheral venous pressure as a measure of venous compliance during pheochromocytoma resection.
Venous pressures measured from peripheral venous catheters (PVP) closely estimate the central venous pressure (CVP) in surgical and critically ill patients. CVP is often used to estimate intravascular volume; however, fluctuations of CVP may also be induced by changes in venous tone caused by alpha-adrenergic catecholamine stimulation. We simultaneously monitored PVP, CVP, and mean arterial blood pressure during resection of pheochromocytoma in a 63-yr-old woman and found excellent correlation between the three pressure variables, suggesting that fluctuations of PVP reflect overall changes in vascular tone.
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Anesthesia and analgesia · Oct 2004
Case ReportsFatal connection: death caused by direct connection of oxygen tubing into a tracheal tube connector.
During cardiopulmonary resuscitation, oxygen extension tubing was mistakenly connected into the tracheal tube connector. As a result, the patient recovering from hypovolemic cardiac arrest died because of pulmonary barotrauma. Similar cases have been reported. We suggest that a worldwide equipment performance standard be developed to prevent future occurrences and describe an example of connectors that would prevent such misconnections.