Anesthesia and analgesia
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Anesthesia and analgesia · Mar 2005
Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain.
Resiniferatoxin (RTX) is a vanilloid agonist with a unique spectrum of activities. Vanilloids bind to the transient receptor potential ion channel subtype 1, a nonselective cation ionophore important in the integration of different noxious signals. Vanilloid agonists selectively decrease sensitivity to noxious stimuli. ⋯ Two hours after incision, the withdrawal threshold was 51 mN without and 456 mN with RTX (P < 0.0001). RTX also prevented the incision-induced decrease in struggle threshold and abolished the pain behavior associated with weight bearing. We conclude that RTX provides a type of neural blockade when postoperative pain is abolished and that nonpainful sensations and motor functions are preserved.
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Anesthesia and analgesia · Mar 2005
Editorial CommentGoldilocks: the pediatric anesthesiologist's dilemma.