Anesthesia and analgesia
-
Anesthesia and analgesia · Jul 2005
Case ReportsSevere anaphylactic shock with methylene blue instillation.
We report a documented severe immunoglobulin E-mediated hypersensitivity reaction associated with use of 1% methylene blue for detection of tubal permeability occurring during general anesthesia. Clinical symptoms, biological assessment results, and cutaneous test positivity confirmed an anaphylactic reaction to methylene blue. This case report confirms the need for systematic allergological investigation of all drugs and substances administered during the perioperative period in the event of a hypersensitivity reaction occurring during anesthesia. Anesthesiologists should be aware of the possibility of hypersensitivity reactions involving any drug or substance used during surgery.
-
Anesthesia and analgesia · Jul 2005
Case ReportsUnusual foreign body airway obstruction after laryngeal mask airway insertion.
Airway obstruction during general anesthesia is fairly common. Foreign body causing obstruction of the laryngeal mask airway is uncommon but can confuse the anesthesiologist trying to troubleshoot the cause of inability to ventilate. We present a case of complete airway obstruction with a nematode caught in the vertical bars of the laryngeal mask airway after its insertion.
-
Anesthesia and analgesia · Jul 2005
The effect of antinociceptive drugs tested at different times after nerve injury in rats.
Given the evolving nature of anatomical and functional changes in the nervous system that are involved in the development of neuropathic pain, it is possible that the differing time course after injury underlies the inconsistent efficacy of drugs in neuropathic pain patients. In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury. ⋯ In contrast, imipramine lacked significant efficacy at 2 and 8 wk postinjury but slightly attenuated mechanical hypersensitivity at 4 wk postinjury. The results show that drug effects may change over time in the neuropathic state, which should be an important consideration in the evaluation of drugs in preclinical animal pain models and has implications for temporal approaches to therapy in the clinic.