Anesthesia and analgesia
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Anesthesia and analgesia · Apr 2007
Intravenous mononuclear marrow cells reverse neuropathic pain from experimental mononeuropathy.
Stem cells mediate neuroprotection in a variety of nervous system injury models. In this study, we evaluated a potential role for stem cells in pain therapies. Marrow mononuclear cells containing mixed stem cell populations were used because of wide experience with these cells in experimental and clinical transplantation. ⋯ These studies suggest that stem or progenitor cell-mediated therapies may be useful for the treatment of pain after nerve injury, and deserve further study to elucidate the mechanisms of analgesia.
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Anesthesia and analgesia · Apr 2007
Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.
Previous work demonstrated that isoflurane and halothane act on the spinal cord rather than on the brain to produce immobility in the face of noxious stimulation. These anesthetics share many effects on specific receptors, and thus do not test the broad applicability of the mediation of immobility by the cord. We sought to test such an applicability by determining whether the cord mediated the immobilizing effects of two aromatic anesthetics that differ greatly in their ability to block N-methyl-d-aspartate receptors. ⋯ These data suggest that HFB, like halothane, produces immobility, predominantly by a spinal cord action, and that HFB differs from ODFB with respect to brain versus spinal sites of action. Nonetheless, although ODFB can produce immobility via a cerebral action, it also can do this via an independent action in the spinal cord. Thus, our results continue to support the spinal cord as the primary site at which inhaled anesthetics, and perhaps propofol, produce immobility.
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Anesthesia and analgesia · Apr 2007
Randomized Controlled TrialThe relative potencies for motor block after intrathecal ropivacaine, levobupivacaine, and bupivacaine.
In this study, we sought to determine the median effective dose (ED50) for motor block of intrathecal ropivacaine, levobupivacaine, and bupivacaine and to define their motor-blocking potency ratios. ⋯ There is a clinical profile of potency for motor block for the pipecolylxylidines when administered spinally: low, intermediate, and high for ropivacaine, levobupivacaine, and bupivacaine, respectively.
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Anesthesia and analgesia · Apr 2007
Randomized Controlled TrialThe effects of arm position on onset and duration of axillary brachial plexus block.
We assessed the effects of arm position after block performance on success rate, onset time, and duration of axillary block (AXB). ⋯ Maintaining the arm in abduction after performing AXB allows a shorter onset time and a prolongation of the sensory and motor blocks.
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Anesthesia and analgesia · Apr 2007
Multicenter Study Comparative StudyFive-year follow-up on the work force and finances of United States anesthesiology training programs: 2000 to 2005.
In the middle 1990s, there was a decrease in anesthesiology residency class sizes, which contributed to a nationwide shortage of anesthesiologists, resulting in a competitive market with increased salary demands. In 1999, a nationwide survey of the financial status of United States anesthesiology training programs was conducted. Follow-up surveys have been conducted each year thereafter. We present the results of the sixth survey in this series. ⋯ These results demonstrate the continuing need for institutional support to keep anesthesiology training departments financially stable.