Anesthesia and analgesia
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Anesthesia and analgesia · Sep 2009
The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.
Peripheral inflammatory pain is associated with an upregulation of spinal cord COX-2 (cyclooxygenase-2), with a subsequent increase in central prostaglandin E2 (PGE2) levels associated with the development of hyperalgesia. In this study, we evaluated the effect of bupivacaine administered via a nerve block or via a systemic route on the spinal expression of PGE2 and COX in a model of peripheral inflammation in rats. ⋯ These results constitute a key element strongly suggesting that local anesthetics act at a different level when administered systematically or via a nerve block.
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Anesthesia and analgesia · Sep 2009
Editorial CommentSpend time on patients and families or on documentation?