Anesthesia and analgesia
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Anesthesia and analgesia · Oct 2010
Comparative StudyThe effect of ketamine anesthesia on the immune function of mice with postoperative septicemia.
It is unknown how ketamine anesthesia immunologically affects the outcome of patients with postoperative septicemia. We investigated the effects of ketamine anesthesia on mice with an Escherichia coli or lipopolysaccharide (LPS) challenge after laparotomy, focusing on phagocytosis by liver macrophages (Kupffer cells) and cytokine production. ⋯ Ketamine suppresses TNF production and phagocytosis by Kupffer cells/macrophages. Therefore, unless bacterial growth is well controlled (by an antibiotic), postoperative infection might not improve despite reduction of the inflammatory response.
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Anesthesia and analgesia · Oct 2010
Comment Letter Case ReportsAnatomic snuffbox radial artery cannulation.