Anesthesia and analgesia
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We developed an IV regional anesthesia (IVRA) model using the tails of rats to allow preclinical evaluation of the safety and efficacy of drugs used in IVRA and analgesia. ⋯ A reliable model for studying IVRA and analgesia has been developed in rats.
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Anesthesia and analgesia · Apr 2010
The relationship among thromboelastography, hemostatic variables, and bleeding after cardiopulmonary bypass surgery in children.
Mediastinal bleeding is common after pediatric cardiopulmonary bypass (CPB) surgery. Thromboelastography (TEG) may predict bleeding and provide insight into likely mechanisms. We aimed to (a) compare perioperative temporal profiles of TEG and laboratory hemostatic variables between patients with significant hemorrhage (BLEED) and those without (CONTROL), (b) investigate the relationship between TEG variables and routine hemostatic variables, and (c) develop a model for prediction of bleeding. ⋯ Hypofibrinogenemia and inadequate heparin reversal are 2 important factors contributing to clot strength and perioperative hemorrhage after pediatric CPB. TEG may be a useful tool for predicting and guiding early treatment of mediastinal bleeding in this group.
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Anesthesia and analgesia · Apr 2010
Reversible conduction block in isolated toad sciatic nerve by emulsified isoflurane.
Studies have shown that the local use of volatile anesthetics can produce local anesthetic effects. We designed this study to evaluate the characteristics of nerve conduction block of emulsified isoflurane (EI) and compare its nerve blockade with 1%lidocaine, by measuring compound nerve action potential (CNAP) parameters in isolated toad sciatic nerve. ⋯ EI produced completely reversible and dose-dependent nerve conduction inhibition, which had slower onset and faster recovery compared with those produced by lidocaine.
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Anesthesia and analgesia · Apr 2010
Special article: a proposal for training in pediatric cardiac anesthesia.
Despite a relatively universally applicable knowledge base and skill set, training and experience in pediatric cardiac anesthesia in currently organized basic anesthesia and Adult Cardiothoracic Anesthesia fellowship programs are very limited and not uniformly available. Experience during Pediatric Anesthesia fellowship training is uniformly available but of limited duration and varying intensity. We present a schema, developed by a working group of the Congenital Cardiac Anesthesia Society, for training in pediatric cardiac anesthesia that pediatric cardiac anesthesia educators internationally should consider as a template to be modified as necessary.