Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2012
Vasopressin-mediated enhancement of adrenergic vasoconstriction involves both the tyrosine kinase and the protein kinase C pathways.
Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. It enhances the vasoconstrictor effects of catecholamines at concentrations of vasopressin that have none or only minimal intrinsic pressor effects. However, the vascular mechanisms underlying this combined pharmacological approach have not been fully elucidated. ⋯ These data are consistent with a central role for TK in mediating both the NE response and the VP-augmented response. Moreover, PYK2 and the µ and γ isoforms of PKC seem to play a preferential role in mediating the augmented VP response. The apparent divergent roles of these pathways in mediating NE- versus VP-augmented pressor responses could potentially lead to new targeted therapies in catecholamine-resistant shock.
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Anesthesia and analgesia · Dec 2012
Editorial Historical ArticleAnesthesia & analgesia by the numbers: then & now.
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Anesthesia and analgesia · Dec 2012
Biography Historical ArticleSpecial article: Nicholas M. Greene: visionary educator, clinician, editor, and humanitarian.