Anesthesia and analgesia
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Anesthesia and analgesia · Aug 2012
The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients.
The activated clotting time (ACT) is widely used for monitoring heparin anticoagulation during cardiac surgery. Celite-based ACT values are prolonged when aprotinin is administered. MDCO-2010, a novel serine protease inhibitor, is currently being evaluated as a possible alternative to aprotinin. Therefore, we evaluated the in vitro effects of this novel agent on ACT values using 3 different point-of-care instruments with kaolin or celite as an activator. ⋯ MDCO-2010 causes less ACT prolongation with kaolin than with celite activation.
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Anesthesia and analgesia · Aug 2012
The systemic and regional hemodynamic effects of phenylephrine in sheep under normal conditions and during early hyperdynamic sepsis.
Phenylephrine treatment of hypotension in sepsis raises concern because it may decrease vital organ bloodflow. Accordingly, we investigated the effects of phenylephrine on systemic and regional bloodflow in normal and septic sheep. ⋯ In sheep with early hyperdynamic sepsis, phenylephrine, at a dose that restored MAP, increased stroke volume and renal bloodflow while decreasing HR and coronary bloodflow but not mesenteric bloodflow. Similar responses were seen in normal animals.
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Anesthesia and analgesia · Aug 2012
Time delay of monitors of the hypnotic component of anesthesia: analysis of state entropy and index of consciousness.
Monitors evaluating the hypnotic component of anesthesia by analyzing the electroencephalogram (EEG) may help to decrease the incidence of intraoperative awareness with recall. To calculate an index representing the anesthetic level, these monitors have different time delays until the correct index is displayed. In previous studies, intraoperatively recorded real and simulated EEG signals were used to determine time delays of cerebral state and Narcotrend and Bispectral indices. ⋯ Time delays were dependent on starting and target index values. Time delays of index calculation may limit the investigated monitor's ability to prevent interoperative awareness with recall. Different time delays for increasing and decreasing transitions could be a problem if the monitors are used for pharmacodynamic studies.