Anesthesia and analgesia
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Anesthesia and analgesia · Aug 2015
The Effects of Blood Glucose Concentration on the Shivering Threshold in Rabbits.
Hyperglycemia is common in critically ill and surgical patients, as are core temperature disturbances. The effect of hyperglycemia on thermoregulatory defenses remains unknown. We determined the effect of blood glucose concentration on the shivering threshold in rabbits. ⋯ Hyperglycemia increases the threshold for shivering, whereas hypoglycemia lowers the threshold on rabbits.
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Anesthesia and analgesia · Aug 2015
Comparative StudySystemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats.
There has recently been a substantial increase in the survival of prematurely born neonates and an increase of in utero surgeries. Noxious stimulation in the newborn alters the pain response to injury in adult life. Progesterone, an effective antihyperalgesic agent in the adult, is at high concentration in the pregnant mother. Therefore, we investigated the effects of early-life progesterone on postsurgical outcomes in adult rats. ⋯ These findings suggest that endogenously high progesterone in utero may have a similarly protective action and that the development of nociceptive circuitry can be strongly influenced by neonatal progesterone.