Anesthesia and analgesia
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Anesthesia and analgesia · Sep 2016
Randomized Controlled Trial Clinical TrialClonidine Does Not Reduce Pain or Opioid Consumption After Noncardiac Surgery.
Clonidine is an α2-adrenoceptor agonist, which has analgesic properties. However, the analgesic efficacy of perioperative clonidine remains unclear. We, therefore, tested the hypothesis that clonidine reduces both pain scores and cumulative opioid consumption during the initial 72 hours after noncardiac surgery. ⋯ Clonidine does not reduce opioid consumption or pain scores in patients recovering from noncardiac surgery.
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Anesthesia and analgesia · Sep 2016
Randomized Controlled Trial Comparative StudyComparative Plasma and Cerebrospinal Fluid Pharmacokinetics of Paracetamol After Intravenous and Oral Administration.
We compared plasma and cerebrospinal fluid (CSF) pharmacokinetics of paracetamol after intravenous (IV) and oral administration to determine dosing regimens that optimize CSF concentrations. ⋯ Peak plasma concentrations were greater and reached earlier after IV than oral dosing. Evidence for differences in CSF Cmax and Tmax was lacking because of the small size of this study.
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Anesthesia and analgesia · Sep 2016
Editorial CommentThe Global Burden of Pain: The Tip of the Iceberg?