Anesthesia and analgesia
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Anesthesia and analgesia · Jan 2017
Fragmented Sleep Enhances Postoperative Neuroinflammation but Not Cognitive Dysfunction.
Sleep is integral to biologic function, and sleep disruption can result in both physiological and psychologic dysfunction including cognitive decline. Surgery activates the innate immune system, inducing neuroinflammatory changes that interfere with cognition. Because surgical patients with sleep disorders have an increased likelihood of exhibiting postoperative delirium, an acute form of cognitive decline, we investigated the contribution of perioperative sleep fragmentation (SF) to the neuroinflammatory and cognitive responses of surgery. ⋯ Although SF and surgery can independently produce significant memory impairment, perioperative SF significantly increased hippocampal inflammation without further cognitive impairment. The dissociation between neuroinflammation and cognitive decline may relate to the use of a sole memory paradigm that does not capture other aspects of cognition, especially learning.
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Anesthesia and analgesia · Jan 2017
Editorial CommentPeripheral Nerve Catheters: Ready for a Central Role?