Anesthesia and analgesia
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Anesthesia and analgesia · May 2017
In the Beginning-There Is the Introduction-and Your Study Hypothesis.
Writing a manuscript for a medical journal is very akin to writing a newspaper article-albeit a scholarly one. Like any journalist, you have a story to tell. You need to tell your story in a way that is easy to follow and makes a compelling case to the reader. ⋯ Therefore, in most clinical and basic science studies and manuscripts, the alternative hypothesis is stated, not the null hypothesis. Also, in the Introduction, the alternative hypothesis is typically stated in the direction of interest, or the expected direction. However, when assessing the association of interest, researchers typically look in both directions (ie, favoring 1 group or the other) by conducting a 2-tailed statistical test because the true direction of the effect is typically not known, and either direction would be important to report.
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Anesthesia and analgesia · May 2017
Topical Ropivacaine in Prevention of Post-Tonsillectomy Pain in Adults.
Post-tonsillectomy pain is 1 of the most intense postoperative pain conditions. However, optimal and sufficient postoperative analgesic treatment remains unclear. We investigated the effect of topical ropivacaine for post-tonsillectomy pain in 160 adult outpatient surgery patients over 2 postoperative weeks. ⋯ Topical ropivacaine failed to reduce pain intensity during the first postoperative week. We observed no major adverse effects.
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Anesthesia and analgesia · May 2017
Inhaled Remimazolam Potentiates Inhaled Remifentanil in Rodents.
Remimazolam is an ester-based short-acting benzodiazepine currently in clinical trials for IV administration. This study explored the feasibility of delivering remimazolam alone and as an adjunct to remifentanil via inhalation in rodent models. ⋯ Remimazolam can significantly potentiate the analgesic effect of remifentanil when concurrently delivered via inhalation.