Anesthesia and analgesia
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Anesthesia and analgesia · Dec 2018
A Systematic Review Evaluating Neuraxial Morphine and Diamorphine-Associated Respiratory Depression After Cesarean Delivery.
The prevalence of neuraxial opioid-induced clinically significant respiratory depression (CSRD) after cesarean delivery is unknown. We sought to review reported cases of author-reported respiratory depression (ARD) to calculate CSRD prevalence. A 6-database literature search was performed to identify ARD secondary to neuraxial morphine or diamorphine, in parturients undergoing cesarean delivery. "Highest" (definite and probable/possible) and "lowest" (definite) prevalences of CSRD were calculated. ⋯ The prevalence of ARD as defined by each individual paper was 61 per 10,000 (95% CI, 51-74). One published case report of ARD met our inclusion criteria, and there were no cases of ARD from the Closed Claims database analysis. These results indicate that the prevalence of CSRD due to neuraxial morphine or diamorphine in the obstetric population is low.
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Anesthesia and analgesia · Dec 2018
Meta AnalysisFluid Challenge During Anesthesia: A Systematic Review and Meta-analysis.
Pulse Pressure Variation and Stroke Volume Variation has limited sensitivity and specificity when assessing the response to intra-operative fluid challenge.
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