Anesthesia and analgesia
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Anesthesia and analgesia · Feb 2020
Observational StudyBody Position Alters Mechanical Power and Respiratory Mechanics During Thoracic Surgery.
During thoracic surgery, patients are usually positioned in lateral decubitus and only the dependent lung ventilated. The ventilated lung is thus exposed to the weight of the contralateral hemithorax and restriction of the dependent chest wall. We hypothesized that mechanical power would increase during one-lung ventilation in the lateral position. ⋯ Mechanical power and lung elastance are increased in the lateral position with one-lung ventilation. Esophageal pressure monitoring may be used to follow these changes.
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Anesthesia and analgesia · Feb 2020
Comparative StudyCalculation of Confidence Intervals for Differences in Medians Between Groups and Comparison of Methods.
Continuous data that are not normally distributed are typically presented in terms of median and interquartile range (IQR) for each group. High-quality anesthesia journals often require that confidence intervals are calculated and presented for all estimated associations of interest reported within a manuscript submission, and therefore, methods for calculating confidence intervals for differences in medians are vital. ⋯ We discuss specific recommendations regarding the methods according to the objectives of the study as well as the distribution of the data as it pertains to the assumptions of the respective methods. Quantile regression allows for covariate adjustment, which may be an advantage in situations where differences in medians between groups may be due to confounding.
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Anesthesia and analgesia · Feb 2020
Exogenous GM1 Ganglioside Attenuates Ketamine-Induced Neurocognitive Impairment in the Developing Rat Brain.
A prolonged exposure to ketamine triggers significant neurodegeneration and long-term neurocognitive deficits in the developing brain. Monosialotetrahexosylganglioside (GM1) can limit the neuronal damage from necrosis and apoptosis in neurodegenerative conditions. We aimed to assess whether GM1 can prevent ketamine-induced developmental neurotoxicity. ⋯ Our data suggest that the exogenous GM1 acts on BDNF signaling pathway to ameliorate the cognitive impairment and hippocampal apoptosis induced by ketamine in young rats. Our study may indicate a potential use of GM1 in preventing the cognitive deficits induced by ketamine in the young per se.