Anesthesia and analgesia
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Anesthesia and analgesia · Jun 1997
Randomized Controlled Trial Clinical TrialPostoperative epidural infusion: a randomized, double-blind, dose-finding trial of clonidine in combination with bupivacaine and fentanyl.
The aim of this randomized, double-blind trial of postoperative thoracic epidural analgesic infusions was to determine whether clonidine at 10 microg/h (group C10, n = 22), 15 microg/h (Group C15, n = 24), or 20 microg/h (Group C20, n = 24) improved postoperative analgesia in patients undergoing abdominal gynecologic surgery, without side effects or hemodynamic changes, when added to a 5-mL/h infusion of 0.125% bupivacaine and fentanyl 2 microg/mL (Group CO, n = 22). The 24-h study infusion was supplemented, as required, by patient-controlled epidural fentanyl. Groups were similar for age, weight, duration, and type of surgery. ⋯ Groups were similar for sedation, pruritus, nausea, time to ambulation, and satisfaction with analgesia. Clonidine produced a dose-dependent decrease in blood pressure and pulse rate and an increase in vasopressor requirement (P < 0.01). Epidural clonidine infused at 20 microg/h improves analgesia during coughing when combined with epidural bupivacaine-fentanyl in patients undergoing lower abdominal surgery but is associated with hemodynamic changes and increased vasopressor requirement.
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Anesthesia and analgesia · Jun 1997
Randomized Controlled Trial Clinical TrialDetermination of the dose-response relationship for intrathecal sufentanil in laboring patients.
Multiple studies have investigated the efficacy of intrathecal opioids, particularly sufentanil, in laboring parturients. However, until the important pharmacological indices of the 50% and 95% effective doses (ED50 and ED95, respectively) are defined, reliable comparative studies among drugs at equipotent doses cannot be performed. This study was performed to establish the dose-response relationship of intrathecal sufentanil analgesia in labor. ⋯ Assisted delivery and cesarean section rates were similar for all groups. Intrathecal sufentanil provides rapid onset of analgesia for labor. The ED50 and ED95 values established in this study should help to provide benchmarks both for the safe clinical use of intrathecal sufentanil for labor and for future comparison studies with other intrathecal analgesic techniques.
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Anesthesia and analgesia · Jun 1997
Randomized Controlled Trial Clinical TrialThe effect of intradermal administration of lidocaine and morphine on the response to thermal stimulation.
Opioids appear to exert a peripheral effect by gaining access to peripheral opioid receptors. It has been proposed that inflammatory processes and highly osmotic substances could alter the perineural barrier, thereby allowing easy access to opioid receptors. Although local anesthetics do not have osmotic activity, they are highly active on neural tissue and appear to work synergistically with opioids when administered for major conduction blockade. ⋯ Pain scores indicated that the combination of lidocaine plus morphine was not more effective than lidocaine alone in attenuating the heat-induced pain. Twenty and 120 min after injection, scores at the lidocaine plus morphine site were 37% and 20% greater than those at the lidocaine site. The addition of morphine to lidocaine did not result in an improvement in the analgesic efficacy and actually had an antianalgesic effect.
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Anesthesia and analgesia · Jun 1997
Case Reports Randomized Controlled Trial Clinical TrialGlossopharyngeal nerve block for pain relief after pediatric tonsillectomy: retrospective analysis and two cases of life-threatening upper airway obstruction from an interrupted trial.
A regional anesthetic technique formerly used in adults for tonsillectomy was adapted to provide posttonsillectomy pain relief in children. Injection of 3-10 mL of 0.25%-0.5% bupivacaine into each lateral pharyngeal space appeared to provide good postsurgical analgesia. A retrospective chart review failed to link the technique to airway-related complications. ⋯ We conclude that the volume and concentration of bupivacaine were sufficient to block the vagus nerves proximal to the take off of the recurrent laryngeal nerves and/or the hypoglossal nerves, resulting in severe UAO. The short distance between the hyoid and jugular foramen would predispose children and adults with a short neck to the development of this complication. In conclusion, bilateral local anesthetic injection into the lateral pharyngeal space may result in severe UAO and loss of protective reflexes.
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Anesthesia and analgesia · Jun 1997
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of propofol with a propofol-ketamine combination for sedation during spinal anesthesia.
Propofol (P) is increasingly used as a sedative during regional anesthesia. Providing titratable sedation and rapid recovery, it can compromise hemodynamic stability. However, in combination with ketamine (K), it provides stable hemodynamics during total intravenous anesthesia, avoiding emergence phenomena. ⋯ Mean arterial pressure was significantly higher in the P + K group, e.g., 91 mm Hg (86-94) vs 75 mm Hg (69-83) at 30 min (mean +/- SD). Administration of vasopressors and fluids as well as recovery and emergence phenomena were similar between groups. Although the described additive effect of propofol and ketamine was not confirmed, the combination conferred hemodynamic stability during spinal anesthesia.