Anesthesia and analgesia
-
Anesthesia and analgesia · Sep 1980
Randomized Controlled Trial Comparative Study Clinical TrialThiopental-nitrous oxide- halothane anesthesia and repeated succinylcholine: comparison of preoperative glycopyrrolate and atropine administration.
The effects of glycopyrrolate and atropine given prior to thiopental-N2O-halothane anesthesia on bradyarrhythmias associated with the administration of succinylcholine were studied and compared. Sixty healthy adult patients were allocated at random to one of three groups. ⋯ ECG monitoring was continuous, and serum K+ levels as well as PaO2 and paCO2 were repeatedly measured. In all three groups patients were adequately and equally protected against serious bradyarrhythmias following the second dose of succinylcholine by atropine and glycopyrrolate in the doses used.
-
Anesthesia and analgesia · Sep 1980
Intravenous albumin administration for prevention of spinal hypotension during cesarean section.
Five percent albumin in Ringer's lactate with 5% dextrose solution (D5RL) (15 ml/kg) was prophylactically infused preanesthetically over 15 to 20 minutes to prevent hypotension during spinal anesthesia in 46 patients undergoing elective cesarean section. Apgar scores and the incidence and severity of hypotension were compared to results obtained in 41 patients who were given D5RL solution without albumin (15 ml/kg). ⋯ The Apgar scores, both at 1 minute and 5 minutes, were significantly higher (p < 0.01) in infants born of mothers given albumin than in infants whose mothers were given D5RL solution. Prophylactic administration of 5% albumin in D5RL solution is an effective method for prevention of spinal hypotension.
-
Anesthesia and analgesia · Sep 1980
Halothane-induced suppression of cell-mediated immunity in normal and tumor-bearing C3Hf/He mice.
The present investigation was designed to demonstrate whether depression of cell-mediated immunity in tumor-bearing hosts is potentiated by halothane anesthesia. Both the in vivo and in vitro effects of halothane anesthesia on splenic lymphocytes from normal and tumor-bearing C3Hf/He mice were examined by lymphocyte transformation. The stimulation index (SI) of lymphocytes from normal C3Hf/He mice exposed to 1.5% halothane/98.5% oxygen anesthesia was significantly less than that of lymphocytes from normal C23Hf/He mice exposed to oxygen (SI of 25.3 and 33.6, respectively) (p < 0.001). ⋯ Lymphocytes from tumor-bearing hosts exposed to 1.5% halothane anesthesia demonstrated diminished lymphocyte transformation compared with those from control (tumor-bearing) mice exposed to oxygen (SI of 1.7 and 4.4, respectively) (p < 0.001). In both tumor-bearing and normal mice, there was a significant suppression of the cell-mediated immune response when the animals were exposed to halothane compared to exposure to oxygen. Results of this investigation demonstrate that halothane anesthesia potentiates the suppression of cell-mediated immunity observed in tumor-bearing hosts.