The Annals of thoracic surgery
-
Because many infants who require cardiac operation have cyanotic heart disease, we determined whether the existing calcium content of St. Thomas' II solution (1.2 mmol/L) is optimal to protect the immature rabbit heart hypoxemic from birth during subsequent ischemia. Modified hypothermic St. ⋯ Thomas' II solution. We conclude that the existing calcium concentration of St. Thomas' II solution is responsible, in part, for its inadequate protection of immature myocardium hypoxemic from birth during ischemia.
-
Biography Historical Article
Will Camp Sealy: surgical innovator, scholar, exceptional teacher, and true Georgian.
Will Camp Sealy, MD, Professor Emeritus of Surgery, Duke University 1984 and Mercer University 1992, was born in Roberta, Georgia, in 1912. A 1936 medical graduate of Emory University, he was in surgical residency training at Duke University from 1936 to 1942. During the next 4 years as an army surgeon in World War II, he was promoted to lieutenant colonel and, in the European theater, made chief of surgery of the 121st General Hospital and later the 128th Evacuation Hospital. ⋯ In 1950, he became chairman of the division of thoracic and cardiovascular surgery, where in the ensuing years he made a number of important initial observations and significant contributions. Among these were studies on the serious paradoxical hypertension that may follow repair of coarctation of the aorta, and on the combined use of hypothermia and perfusion for open heart surgical procedures. In more recent years, his initiation and landmark studies of the surgical treatment of certain cardiac arrhythmias have gained him worldwide recognition and opened one of the last frontiers of cardiac surgery.
-
The effects of different cardioplegia temperatures on myocardial protection with continuous aerobic blood cardioplegia were studied in a canine model of acute regional injury after left anterior descending coronary artery occlusion and subsequent revascularization. Twenty-five animals underwent 90 minutes of occlusion followed by revascularization during 60 minutes of electromechanical arrest with continuous retrograde blood cardioplegia delivered at one of three temperatures: 18 degrees C (n = 8), 28 degrees C (n = 8), and 37 degrees C (n = 9). Left ventricular protection was assessed in a right heart bypass model in terms of the left ventricular pressure-volume relationships, myocardial oxygen consumption, regional myocardial blood flow, adenosine trisphosphate concentration, and water content. ⋯ The maximum elastance and stress-strain relationships showed there were no significant differences between the groups at 90 minutes. The myocardial oxygen consumption was greatest in the 37 degrees C group during the first hour after reperfusion (18 degrees C, 5.4 +/- 1.4 mL O2.min-1.100 g-1; 28 degrees C, 4.7 +/- 1.1 mL O2.min-1.100 g-1; 37 degrees C, 6.3 +/- 1.6 mL O2.min-1.100 g-1; p < 0.05). The regional myocardial blood flow, adenosine triphosphate concentration, and myocardial water content were similar in the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
-
During a 15-month period, a subxiphoid pericardial window was performed as a diagnostic method to rule out cardiac injury in 76 patients with penetrating wounds near the heart. Patients with an obvious diagnosis of cardiac tamponade or patients in severe shock were excluded. Seventy-four patients were male, and 2 were female. ⋯ In 16 patients (21%), the procedure identified hemopericardium. In our hands, the subxiphoid pericardial window has proved to be a rapid, precise, and safe method for the diagnosis of wounds of the heart. Until a less invasive procedure proves more precise, we recommend it as the standard diagnostic approach for cardiac injuries in patients in stable condition.