Transplantation proceedings
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An 11-year retrospective review (1993 to 2003) of 102 severe burn patients (>40% total body surface area and undergone wound excision surgery) was performed to determine the efficacy of early wound debridement and coverage of large burns with skin allografts, a treatment introduced here in 1998 with the establishment of a skin banking facility. While there was no significant reduction in mortality, length of hospital stay decreased by 15.7 days (P < .05) during the post-skin-banking period. Skin allograft donation rates from multiorgan donors were consistently fewer compared with corneal donation, mainly due to strong cultural beliefs and public misconceptions regarding skin harvesting. The overall tissue donation rate in Singapore may improve if efforts focus on deceased cases sent to the state coroner where retrieval and counseling can be centralized.
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Chronic pain is prevalent in end-stage renal disease patients undergoing chronic hemodialysis. We do not fully know the intensity of chronic pain experienced by kidney recipients in comparison to those on chronic hemodialysis and healthy controls. Moreover, the effect of chronic pain on kidney recipients' health-related quality of life (HRQoL) is yet to be comprehensively addressed. We designed this study to find an answer to these questions. ⋯ The intensity of chronic pain experienced by the kidney recipients is less than that experienced by patients under chronic hemodialysis, but higher than healthy subjects. Focusing on chronic pain as a cause of post-renal transplantation morbidity is expected to improve post-renal transplantation quality of life.
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Although some studies have described rehospitalization after transplantation, few have focused on risk factors and consequences of prolonged hospital stay. Our goal was to determine the causes, risk factors, and outcomes of prolonged rehospitalizations after renal transplantation. ⋯ In this study, we found that prolonged hospital stays accounted for >62% of all hospital costs; however, they comprised only 26% of the patients. High-risk kidney transplant recipients for prolonged hospitalizations should be closely observed for infections and graft rejection.
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There are 3 major obstacles to performing transplantations from pig to human. They are as follows: a powerful immune barrier, a potential risk for transmitting microorganisms, particularly endogenous retrovirus from animal-to-human, and ethical issues related to patients and society at large. ⋯ Donation from deceased or live human beings will become obsolete. Furthermore, it will be possible to alleviate graft rejection by genetic modification of the source animal.