Transplantation proceedings
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This study evaluated the safety and efficacy of Stilamin (Somatostatin) in the treatment of lymphatic leaks after living-related renal transplanatation. ⋯ Stilamin administration is a safe and effective treatment for lymphorrhea after kidney transplanation.
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Because the donor shortage is extremely severe in Japan because of a strict organ transplantation law, special strategies have been established to maximize heart and lung transplantations (HTs and LTs, respectively). We reviewed 100 consecutive brain-dead donors to evaluate our strategies to identify and manage heart and lung donors. ⋯ Although the number of cases was still small, the availability of organs has been greater and the outcomes of HT/LT acceptable.
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Hemodynamic instability is a frequent complication in potential organ donors. Despite maximal medical therapy, it can lead to cardiac arrest with consequent loss of organs. In this study we present the use of extracorporeal membrane oxygenation circulation (ECMO) as a bridge to organ procurement in a potential donor with hemodynamic instability. ⋯ We retrieved liver, kidneys, heart valves and cornea. Liver and kidney transplantations were successfully performed in 3 recipients, all of whom displayed appropriate organ functions after 15 months. In conclusion, ECMO support of potential donors can be used to prevent cardiac arrest, preserve organs, and thus increase the number of potential donors.
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Various biomarkers have been studied for diagnosing bacterial infections, seeking to stop the sepsis cascade. Presepsin, which is ∼13 kDa in size, has been identified to increase specifically in the blood of sepsis patients. Additionally, measurement of presepsin is useful to evaluate the severity of infection and monitor clinical responses. We evaluated the analytical and clinical performance of the Pathfast presepsin (PFP) assay system for early diagnosis of infection. ⋯ The PFP test had a (100%) sensitivity to show the presence of infection in a short time (15 min), confirmed by positive blood cultures.
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Primary graft dysfunction (PGD) might occur after lung transplantation. In some severe cases, conventional therapies like ventilatory support, administration of inhaled nitric oxide (iNO), and intravenous prostacyclins are not sufficient to provide an adequate gas exchange. The aim of our study was to evaluate the use of a lung protective ventilation strategy associated with a low-flow venovenous CO2 removal treatment to reduce ventilator-associated injury in patients that develop severe PGD after lung transplantation. ⋯ The use of LFVVECCO2R together with a protective lung ventilation strategy during the perioperative period of lung transplantation may be a valid clinical strategy for patients with PGD and severe respiratory acidosis occured despite adequate mechanical ventilation.