International journal of dermatology
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Case Reports
Acute generalized exanthematous pustulosis: analysis of cases managed in a tertiary hospital in Singapore.
ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS: We reviewed eight cases of acute generalized exanthematous pustulosis managed in a tertiary hospital in Singapore. ⋯ Acute generalized exanthematous pustulosis is generally described as benign and self-limiting. However, in certain patients, the clinical course is prolonged and may exhibit features that overlap with other forms of cutaneous adverse drug reactions such as toxic epidermal necrolysis and DRESS.
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Letter Case Reports
Scalp necrosis as a manifestation of temporal arteritis.
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Goeckerman therapy (GT) for psoriasis is based on cutaneous application of crude coal tar [polycyclic aromatic hydrocarbons (PAH)] and exposure to ultraviolet radiation (UVR). PAH and UVR are mutagenic, carcinogenic and immunotoxic agents that promote apoptosis. ⋯ Our results demonstrate high dermal absorption of PAH during GT and provide evidence that GT promotes genotoxicity and apoptosis.
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Comparative Study
Comprehensive understanding of idiopathic guttate hypomelanosis: clinical and histopathological correlation.
The histological findings associated with idiopathic guttate hypomelanosis (IGH) are hyperkeratosis, an atrophic epidermis, and flattened rete ridges. In addition, a decreased melanin content and reduced numbers of melanocytes are reported features. However, there are few recent studies that have been published on the histopathology of IGH and no comparative studies are available on the skin lesions and perilesional skin of patients with IGH. ⋯ Idiopathic guttate hypomelanosis is a disorder with multifactorial etiology; its pathogenesis may depend on various factors such as patient age and sun-exposure. Histopathologically, hyperkeratosis was frequently found; however, the other characteristic findings such as epidermal atrophy and flattened rete ridges were relatively rare.