International journal of dermatology
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Lymphangiomas are congenital malformations of the lymphatic system that may involve the skin, subcutaneous tissues, and intestines. They account for 4% of all vascular tumors, but comprise 25% of benign vascular growths in children. ⋯ CLC appears localized to the dermis, although frequently extends deeper and laterally. It is important to distinguish CLC, a potentially recurrent disease, from an unusual type of metastatic carcinoma of the skin called carcinoma telangiectoides.
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Randomized Controlled Trial Multicenter Study
Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies.
Data suggest that photodynamic therapy using topical methyl aminolevulinate (MAL PDT) may be a noninvasive alternative to excisional surgery for nodular basal cell carcinoma (BCC). In the studies described here, we investigated the histologic response, tolerability, and cosmetic outcome with MAL PDT for primary nodular BCC (
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Case Reports
A histopathologic study of mechanic's hands associated with dermatomyositis: a report of five cases.
Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. ⋯ The histopathologic findings of mechanic's hands are specific and different from those of eczema. A histopathologic examination is useful for the diagnosis of mechanic's hands associated with dermatomyositis and a high incidence of interstitial pneumonia.
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Case Reports
Lamellar ichthyosis with a novel homozygous C-terminal mutation in the transglutaminase-1 gene.
The majority of cases of Lamellar ichthyosis (LI) are caused by mutations in the transglutaminase-1 (TGM1) gene. The mutations in the beta-barrel domains of the TGM1 gene are found very infrequently and several authors have suggested that these domains are not essential for the function of the enzyme. Other authors have postulated that mutations in these loci are pathogenic but they imply a less severe clinical picture of LI. ⋯ This finding indicates that the integrity of beta-barrel domains is important for the correct function of the enzyme and that we are still far away from a consistent genotype-phenotype correlation.