Indian pediatrics
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In contrast to adults, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually leads to a mild illness in children. However, a few children have been reported to have severe manifestations including pneumonia, acute kidney injury, multi-organ failure and cardiac injury. This review focuses on cardiac involvement during SARS-CoV-2 infection and the recently described likely immune mediated post-COVID-19 syndrome. Therapeutic strategies for cardiac dysfunction in both these settings are briefly discussed.
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Review
COVID-19 Associated Hemophagocytic Lymphohistiocytosis and Coagulopathy: Targeting the Duumvirate.
Preliminary data on coexistence of secondary hemophagocytic lymphohistiocytosis syndrome (HLH) and disseminated intravascular coagulation (DIC) in critically ill children with novel coronavirus disease (COVID-19) are emerging. Herein, we summarize the available literature and fill-in the gaps in this regard. ⋯ HScore can be used as a complement to clinical decision for initiating immunosuppression. Children with moderate-to-severe COVID-19, especially those with documented thrombocytopenia or chilblains, should be regularly monitored for coagulopathy.