Indian pediatrics
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Meta Analysis
Intermittent or daily short course chemotherapy for tuberculosis in children: meta-analysis of randomized controlled trials.
To compare the effectiveness of intermittent with daily chemotherapy (both containing rifampicin) in childhood tuberculosis (age 16yrs) in achieving cure significant improvement. ⋯ Twice weekly intermittent short course therapy is less likely to cure tuberculosis in children as compared to daily therapy. There is a need for better quality randomized controlled trials for assessing efficacy of alternate schedule for intermittent therapy for childhood tuberculosis.
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We conducted this study to evaluate the outcome of 203 patients admitted to PICU, using PRISM score. Overall mortality was 16.7%. ⋯ A cut off score of 15 was associated with 89.2% accuracy. PRISM score is highly sensitive in predicting the outcome of pediatric patients in an ICU setting.
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We retrospectively compared body surface area (BSA) using the Mosteller formula square root(H x (w/360)) and a simple weight-based BSA formula ([4Wkg+7]/ [90+Wkg]). The participants were 363 children who underwent cardiac surgery from 1991 to 2000. ⋯ We propose that the weight-based formula is easy to use and accurate. It can safely replace Mosteller formula and dispense the need for time-consuming calculations.
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We conducted this study to find out the incidence of extubation failure (EF) in ventilated neonates and associated clinical risk factors. Eighty two ventilated neonates were followed up to 48 hours post extubation to look for EF. Twenty two babies (26.8%) had EF. ⋯ The duration of ventilation, and maximum and pre-extubation alveolar arterial oxygen gradients (AaDO2) were significantly higher (P<0.05) in EF group. The incidence of sepsis (P=0.034), anemia (P=0.004) and pneumonia (P=0.001) were significantly higher in EF group. Detection of significant PDA and adequate post extubation care may help to reduce rate of extubation failure in neonates.
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To investigate the relationship between score for neonatal acute physiology II (SNAP II) applied within 12 hours from the onset of severe sepsis, and death and persistent organ dysfunction (OD). ⋯ Severely septicemic neonates with high SNAP II scores (>40) have a higher risk of dying and persistent organ dysfunction. Individual SNAP II parameters do not contribute equally in prediction of mortality.