Headache
-
Case Reports
Can indomethacin act as a disease modifying agent in hemicrania continua? A supportive clinical case.
The natural history of hemicrania continua (HC) is not well-known. Most sufferers have the unremitting form and thus may have a lifetime duration of pain. ⋯ The question arises: Does indomethacin have disease-modifying capacities for HC or does it just suppress the pain without altering the underlying disease pathogenesis? A case patient is presented who had indomethacin-responsive unremitting HC and after a period of daily use of indomethacin she was able to reduce her dose to one single 25-mg tablet 3 days per week and still remain pain free, suggesting disease modification. The case patient's history will be further discussed as well as the consideration that in some instances indomethacin can alter the natural history of HC.
-
Randomized Controlled Trial Multicenter Study
Rizatriptan 10-mg ODT for early treatment of migraine and impact of migraine education on treatment response.
To examine the efficacy of rizatriptan 10-mg orally disintegrating tablet (ODT) for treating migraines of mild intensity soon after onset, with or without patient-specific migraine education. ⋯ Rizatriptan 10-mg ODT, when taken early, while headache pain is mild, was superior to placebo at providing pain freedom at 2 hours and 24-hour sustained pain freedom.
-
Randomized Controlled Trial
Botulinum toxin a in the treatment of chronic tension-type headache with cervical myofascial trigger points: a randomized, double-blind, placebo-controlled pilot study.
To evaluate the efficacy of botulinum toxin A (BT-A) as a prophylactic treatment for chronic tension-type headache (CTTH) with myofascial trigger points (MTPs) producing referred head pain. ⋯ The evidence for BT-A in headache is mixed, and even more so in CTTH. However, the putative technique of injecting BT-A directly into the ubiquitous MTPs in CTTH is partially supported in this pilot study. Definitive trials with larger samples are needed to test this hypothesis further.
-
To compare and contrast body mass indices calculated based on self-reported height and weight as compared with measured height and weight in migraine patients. ⋯ In our study, the self-reported mean weight and BMI for migraineurs was significantly less than the measured mean weight and BMI, and was of greater magnitude in the obese migraineurs. This suggests that conclusions drawn from studies evaluating obesity utilizing self-reported BMI in migraineurs may undercall the effect of total body obesity.
-
This study examined modulation of trigeminal pain/nociception by 2 supraspinal mechanisms: emotional controls of nociception and diffuse noxious inhibitory controls. ⋯ Emotional controls and diffuse noxious inhibitory controls modulated trigeminal pain and emotional controls modulated trigeminal nociception. These procedures can be used to study supraspinal modulation of nociceptive processing in disorders of the trigeminal pain system, including headache.