Headache
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Multicenter Study Comparative Study Clinical Trial
Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract.
To explore the role of a special butterbur root extract for migraine prevention in children and adolescents with severe migraines. ⋯ The results and low rate of adverse events in this open prospective migraine prevention study in children and adolescents are similar to the results of two multicenter placebo-controlled butterbur studies in adults. Butterbur root extract shows a potential as an effective and well-tolerated migraine prophylaxis also for children and teenagers.
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We present a case of severe posterior headache and diplopia following an epidural steroid injection for lumbar pain.
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Multicenter Study
Clinical characteristics and patterns of medication use of migraneurs in Latin America from 12 cities in 6 countries.
The objective of this study was to document the clinical characteristics of migraine and patterns of medication use in residents > or =15 years old in 12 Latin American urban communities. ⋯ Migraine is a common disorder in Latin American urban communities imposing significant burden on individuals, families, and communities. The magnitude of the impact and the range of activities affected by migraine are similar to those of previous reports in other regions. The preponderance of nonprescription medications and the scarcity of migraine-specific triptans from the study findings are especially striking.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Zolmitriptan 5 mg nasal spray: efficacy and onset of action in the acute treatment of migraine--results from phase 1 of the REALIZE Study.
The objective of phase 1 (reported here) of this two-phase study was to assess the efficacy of zolmitriptan 5 mg nasal spray, in terms of ability to provide relief from all migraine symptoms, in a controlled setting, designed to replicate clinical practice. ⋯ These findings confirm the efficacy demonstrated by zolmitriptan nasal spray in previous clinical trials.