Gut
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A feeding tube can be rapidly introduced into the small intestine through a makeshift 'external channel' of the fibreoptic endoscope. To prevent dislodgement of the feeding tube upon withdrawal of the endoscope, the former may be stabilized by means of the biopsy forceps introduced through its regular channel.
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Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial
Proceedings: A controlled comparison of highly selective vagotomy against truncal vagotomy and pyloroplasty for duodenal ulcer.
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Clinical Trial Controlled Clinical Trial
The use of fresh frozen plasma or a concentrate of factor IX as replacement therapy before liver biopsy.
Thirty patients with various types of chronic liver disease and a prothrombin time prolonged for four or more seconds who required needle liver biopsy for diagnostic purposes were given either fresh frozen plasma or a concentrate of clotting factors as a prophylactic measure. The prothrombin time returned to within normal limits in seven of the 15 patients given the concentrate and in three of those receiving fresh frozen plasma. Levels of factors II, IX, and X showed increases of about 30% following concentrate administration; corresponding rises in the group given fresh frozen plasma were less. ⋯ In neither group was there clinical evidence of bleeding, but it was of interest that most of the clotting factor levels, except in factor II, before biopsy were above those normally required for haemostasis. No evidence of disseminated intravascular coagulation was found with the concentrate injection, and the most worrying finding was the appearance of HBAg some months later in three patients, two from the concentrate group and one from those given fresh frozen plasma. However, the conversion of these patients to HBAg positive may be unrelated to the clotting factor replacement therapy.
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Randomized Controlled Trial Clinical Trial
Proceedings: The importance of bacteroides as a cause of severe sepsis after colo-rectal surgery.
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Randomized Controlled Trial Clinical Trial
A controlled trial of heparin therapy in the coagulation defect of paracetamol-induced hepatic necrosis.
Treatment of the coagulation disturbances developing with hepatic damage following a paracetamol overdose was assessed in a controlled trial of 22 patients, one half being given heparin and fresh frozen plasma and the other fresh frozen plasma alone. No significant difference was observed either in the speed of correction of the coagulation defect or in the clinical outcome. Two-thirds of the patients had evidence of disseminated intravascular coagulation, but despite the presence of a severe coagulation defect, significant bleeding occurred in only five patients. This may be because with paracetamol-induced hepatic necrosis both the coagulation defect (and possibly other features attributable to severe hepatic insufficiency) are of shorter duration than in hepatic necrosis due to causes such as viral hepatitis in which the liver damage may be a continuing process.