The Journal of experimental medicine
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In the study of the action of non-antiseptic substances on the rate of cicatrization, the chief obstacle encountered is the facility with which wounds become reinfected under an aseptic dressing. At the beginning of Experiment 1 the wound was sterile. It was subjected to flushing with distilled water for 2 hours, then to flushing with 30 per cent sodium chloride solution for another 2 hours. ⋯ But it seems that a tissue with normal circulation is protected by it against the changes of the osmotic pressure occurring at its surface. The above experiments show that apparently the conditions of the tissues of a wound are not modified by the changes of the osmotic pressure of the dressing. The beneficial effects of hypertonic sodium chloride solution on the sterilization of wounds and on the rate of healing recently described by various surgeons are possibly an illusion due to lack of precise technique.
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1. The Wallerian degeneration occurring in peripheral nerves by incubation in Ringer solution and serum does not occur in plasma. 2. Peripheral nerves incubated in plasma give rise to no growth. ⋯ In no case was growth of axis cylinders observed. 5. The growth of the syncytium of Schwann from degenerating nerves affords a basis for an anatomical conception of the centrifugal orientation of growing axis cylinders in regeneration. 6. Morphologically there is a striking resemblance between the syncytium of Schwann and neuroglia growing in plasma.
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1. The placental blood film examination is worthy of routine application wherever aestivo-autumnal malaria is endemic. This type of malaria when associated with labor and the early days of the puerperium can be more easily and certainly diagnosed by the use of this film and a polychrome stain than by employing the usual films made from the mother's peripheral blood at the time of labor. ⋯ The racial disparity of malarial infections shown in this series is believed to be due to local conditions and a wrong impression is apt to be given by our statistics in regard to the relative immunity of the negro race. The white women on the Canal Zone avail themselves of all the opportunities the sanitary system affords; they live well and place the entire course of their pregnant state under competent professional care, while the negro woman is indifferent to her pregnant state, works as a domestic servant, and lives in the cheapest unprotected quarters that can be rented in the suburban divisions of Panama City where the malarial rate is highest and the sanitary control is difficult. It should be noted that these negro women can carry an infection with little manifestation of its presence that would produce serious results in the white women brought from the temperate zone regions of Europe and the United States.
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If we now consider briefly the principal results of our investigation, we can, in comparing the behavior of the thyroid after auto- and homeoplastic transplantation, in general recognize three stages. In the first stage, comprising the first 4 to 5 days after transplantation, there is no noticeable difference between the auto- and homeograft; both corresponding pieces behave in the main alike; large parts of both grafts become necrotic in the center; the necrosis begins shortly after the transplantation and concerns only a part of the periphery; here a narrow zone of thyroid tissue is left; it consists of one to two rows of partly well recognizable follicles. After 48 hours the first fibroblasts, polynuclear leucocytes, and lymphocytes appear in the tissue surrounding the grafts. ⋯ In some homeografts destruction by means of lymphocytes, in others by connective tissue, preponderates. The rapidity with which the destruction takes place in different homeotransplants also varies. A much better blood vessel supply develops in the autograft than in the homeograft.
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Subcutaneous injections of adrenalin are, in contrast with its behavior in the production of the other effects of that drug, more favorable to the production of glycosuria in rabbits than intramuscular injections; the failures are fewer and the quantities of dextrose in the urine are generally larger. In general, as regards the stimulation of diuresis by adrenalin, a subcutaneous injection exerts generally a greater effect than an intramuscular one. Subcutaneous injections of a certain dose of adrenalin distributed over several areas are far less effective than the administration of that dose in a single injection; they fail frequently to produce any glycosuria, the quantity of dextrose in the urine, when present, being less, and the quantity of urine being generally diminished. Apparently the more slowly the injected adrenalin reaches the blood, the greater is its effect in producing glycosuria and generally, also, the greater its diuretic action.