Annual review of medicine
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Lung transplantation has become a therapeutic option for appropriately selected patients with end-stage lung disease. Recipient selection guidelines are summarized, and the timing of transplantation is discussed. Functional results and survival statistics are reviewed.
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Annual review of medicine · Jan 1992
ReviewPrinciples of mechanical ventilator use in respiratory failure.
Recent advances in our knowledge of the pathophysiology of acute and chronic respiratory failure have significantly revised our strategies for ventilatory support. Gas exchange, muscle function, barotrauma, and the course and prognosis of the mechanically ventilated patient are now better understood. Furthermore, impressive technological innovations have enabled the clinician to monitor patient-ventilator interactions closely and to undertake ventilatory approaches unthought of only a short time ago. The purpose of this review is to highlight key management principles and therapeutic options that derive from our improved understanding of respiratory failure and its treatment.
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Annual review of medicine · Jan 1991
ReviewLipoprotein transport gene abnormalities underlying coronary heart disease susceptibility.
There is a close association between lipoprotein abnormalities and coronary heart disease susceptibility. Since 1982, the genes for the lipoprotein transport proteins have been isolated and at least partially characterized. Mutations in these genes are now being defined that underlie the common abnormalities found in heart attack victims. This review presents our current state of knowledge on this subject.
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Annual review of medicine · Jan 1990
ReviewThe resurgence of acute rheumatic fever in the United States.
The incidence of acute rheumatic fever (ARF) had been declining in the United States for decades, and by the late 1970s ARF had become a rare disease in most areas of the country. The mid-1980s saw a resurgence of ARF, with reported outbreaks in Utah, Ohio, Pennsylvania, and military recruit camps in Missouri and California, as well as sporadic cases in many other communities. This review summarizes salient epidemiologic data related to the resurgence, explores some possible explanations for its occurrence, and discusses strategies for prevention of rheumatic fever now and in the future.
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Annual review of medicine · Jan 1989
ReviewBurn unit treatment of acute, severe exfoliating disorders.
In this chapter, we review the experience gained in the burn unit treatment of two of the severe exfoliating disorders, toxic epidermal necrolysis (TEN) and the Stevens-Johnson syndrome (SJS). Septic mortality was higher if high doses of corticosteroids were given versus the current protocol, which avoids these drugs. Current controversies include the role of topical therapy, leukopenia, and invasive catheters in septic complications as well as nutritional requirements. Concomitant viral infection and the macrophage may each play a role in the etiology of TEN and SJS.