Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Sep 2002
Dermal microdialysis provides evidence for hypersensitivity to noradrenaline in patients with familial dysautonomia.
To use the technique of dermal microdialysis to examine sensitivity of skin vessels to noradrenaline (NA) in patients with familial dysautonomia (FD) and in healthy controls. ⋯ These data support the hypothesis that peripheral blood vessels of patients with FD show a denervation hypersensitivity to catecholamines. This may be one mechanism contributing to the major hypertension that frequently occurs during "dysautonomic crises" in FD.
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In the diagnosis of functional weakness and sensory disturbance, positive physical signs are as important as absence of signs of disease. Motor signs, particularly Hoover's sign, are more reliable than sensory signs, but none should be used in isolation and must be interpreted in the overall context of the presentation. It should be borne in mind that a patient may have both a functional and an organic disorder.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2002
Impact of early intervention on outcome following mild head injury in adults.
The impact of mild head injury is variable and determinants of outcome remain poorly understood. Results of previous intervention studies have been mixed. ⋯ The provision of an information booklet reduces anxiety and reporting of ongoing problems.