Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
ReviewHuman cellular inflammation in the pathology of acute cerebral ischaemia.
Leucocytes form important effector pathways for inflammation. This article reviews the clinical evidence for the presence of a cellular inflammatory response in cerebral ischaemia, and attempts to define its temporal profile and spatial distribution. The processes involved in recruitment and activation of leucocytes in this context are addressed, and the successes and failures of interventions aimed at these processes discussed.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Clinical TrialMood changes with deep brain stimulation of STN and GPi: results of a pilot study.
The results of this study suggest that there are mood changes associated with deep brain stimulation of the subthalamic nucleus (STN) and the globus pallidus interna (GPi). Further, optimal placement of electrodes in both STN and GPi seems to result in overall improvement in mood and is associated with a lower incidence of adverse mood effects than stimulation outside the optimal site. Preliminary data from this study, however, suggest that slight movement dorsal or ventral to the site of optimal motor performance may be associated with more adverse changes in mood with STN stimulation than with GPi stimulation.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2003
Biography Historical ArticleCerebral embolism in endocarditis: William Senhouse Kirkes (1823-64).