Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Aug 2003
Biography Historical ArticleCruveilhier and acoustic neuroma.
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Over the last 30 years neurovirology has emerged as a major discipline which has much relevance to both human disease and many aspects of neuroscience. This overview of the field aims to define briefly most of the major neurovirological techniques, both "classical" and more recent, and to indicate how these have been used to gain knowledge about the pathogenesis, clinical investigation, and treatment of viral infections of the central nervous system.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2003
Pituitary deficiency following aneurysmal subarachnoid haemorrhage.
To investigate the incidence and severity of pituitary insufficiency after aneurysmal subarachnoid haemorrhage. ⋯ Persistent pituitary dysfunction may be more common after aneurysmal subarachnoid haemorrhage than has so far been recognised and warrants further investigation, given the possibility that some health and neurobehavioural problems in these patients could result from hormone deficiency.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2003
Comparative StudyThe management of refractory generalised convulsive and complex partial status epilepticus in three European countries: a survey among epileptologists and critical care neurologists.
To survey the current clinical treatment of refractory status epilepticus and to identify steps in its management which may need further investigation. ⋯ The management of refractory status epilepticus is heterogeneous in many aspects, even among clinicians who are most familiar with this severe condition. Randomised trials are needed to compare the efficacy, side effects, optimal duration, and depth of general anaesthesia.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2003
Long term neuropsychological outcome after head injury: relation to APOE genotype.
Existing evidence suggests that some patients who sustain a head injury suffer cognitive decline many years later, and that head injury and possession of the APOE epsilon 4 allele are each risk factors for Alzheimer's disease. ⋯ Although this study provides additional evidence that a late decline may occur after head injury, there was no clear relation to APOE genotype. Despite the follow up interval of 15 to 25 years, the cohort is still too young (mean age 42.1 years) to assess the risk of Alzheimer's disease.