Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2008
Multicenter StudyLong-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study.
Critical illness myopathy (CIM) and polyneuropathy (CIP), alone or in combination (CIP/CIM), are frequent complications in patients in the intensive care unit (ICU). There is no evidence that differentiating between CIP and CIM has any impact on patient prognosis. ⋯ CIM has a better prognosis than CIP. Differential diagnosis is important to predict long-term outcome in ICU patients.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2008
Controlled Clinical TrialSkin wrinkling for diagnosing small fibre neuropathy: comparison with epidermal nerve density and sympathetic skin response.
To compare simple tests of small nerve fibre function with intraepidermal nerve fibre density (IENFD) in the evaluation of small fibre neuropathy (SFN). ⋯ Stimulated skin wrinkling was nearly as sensitive as IENFD in diagnosing SFN, whereas SSR was of less use. Stimulated skin wrinkling is a useful supportive test when IENFD or other tests of small nerve fibre function are not available.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2008
Blood-brain barrier disruption in post-traumatic epilepsy.
Traumatic brain injury (TBI) is an important cause of focal epilepsy. Animal experiments indicate that disruption of the blood-brain barrier (BBB) plays a critical role in the pathogenesis of post-traumatic epilepsy (PTE). ⋯ Lasting BBB pathology is common in patients with mild TBI, with increased frequency and extent being observed in patients with PTE. A correlation between disrupted BBB and abnormal neuronal activity is suggested.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2008
Haplotypes of the fibrinogen gene and cerebral small vessel disease: the Rotterdam scan study.
Fibrinogen levels and fibrinogen clot structure have been implicated in the pathogenesis of vascular disease. We examined fibrinogen levels and variation in fibrinogen genes (fibrinogen gamma (FGG), alpha (FGA) and beta (FGB)), which have been associated with fibrin clot structure and fibrinogen levels, in relation to cerebral small vessel disease (SVD). ⋯ Our study provides evidence for an association of common variation in the FGG and FGA genes with cerebral SVD. It is possible that the structure of the fibrin clot rather than plasma fibrinogen levels plays a role in the pathogenesis of cerebral SVD.