Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
The Severity of Dependence Scale detects people with medication overuse: the Akershus study of chronic headache.
To evaluate the Severity of Dependence Scale (SDS) in people with primary chronic headache and analyse the pattern of medication overuse. ⋯ The SDS questionnaire detects medication overuse and dependency-like behaviour in persons with primary chronic headache.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Comparative Study Clinical TrialBrain penetration effects of microelectrodes and DBS leads in STN or GPi.
To determine how intraoperative microelectrode recordings (MER) and intraoperative lead placement acutely influence tremor, rigidity, and bradykinesia. Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi)). ⋯ This study demonstrated significant acute intraoperative penetration effects resulting from MER and lead placement/collision in PD. Clinicians rating patients in the operating suite should be aware of these effects, and should consider pre- and post-lead placement rating scales prior to activating DBS. The collision/implantation effects were greater intraoperatively with STN compared with GPi, and with greater disease duration there was a larger effect.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Multicenter StudyFunctional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia.
To compare rates of mild cognitive impairment (MCI) and rates of progression to dementia using different MCI diagnostic systems. ⋯ Different criteria produce different MCI rates and different conversion rates to dementia. Although a higher percentage of MCI was identified by CDR than NP, a higher percentage of NP MCI progressed to dementia. These findings suggest that the CDR is sensitive to subtle changes in cognition not identified by the NP algorithm but is also sensitive to demographic and clinical factors probably leading to a greater number of false positives. These results suggest that identifying all individuals with CDR scores of 0.5 as Alzheimer's disease is not advisable.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Multicenter StudyAssociation between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Although there is evidence that vitamin D inadequacy may be linked to adverse cognitive outcomes, results from studies on this topic have been inconsistent. The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men. ⋯ In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.
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J. Neurol. Neurosurg. Psychiatr. · Jul 2009
Case ReportsRelatively preserved knowledge of music in semantic dementia.
The brain basis for music knowledge and the effects of disease on music cognition are poorly understood. Here we present evidence for relatively preserved knowledge of music in a musically untrained patient with semantic dementia and characteristic asymmetric anterior temporal lobe atrophy. Our findings suggest that music is partly separable neuropsychologically and anatomically from other semantic domains, with implications for the clinical management of patients with brain disease.