Journal of neurology, neurosurgery, and psychiatry
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This review summarises exciting recent and forthcoming advances that will impact on the surgical management of epilepsy in the near future. This does not cover the current accepted diagnostic methodologies or surgical treatments that are routinely practiced today. The content of this review was derived from a PubMed literature search, using the key words 'Epilepsy Surgery', 'Neuromodulation', 'Neuroablation', 'Advances', between 2010 and November 2013.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialOral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.
This double-blind, placebo-controlled, dose-finding phase IIb study evaluated the efficacy and safety of ponesimod, an oral selective S1P1 receptor modulator, for the treatment of patients with relapsing-remitting multiple sclerosis (RRMS). ⋯ Once-daily treatment with ponesimod 10, 20 or 40 mg significantly reduced the number of new T1 Gd+ lesions and showed a beneficial effect on clinical endpoints. Ponesimod was generally well tolerated, and further investigation of ponesimod for the treatment of RRMS is under consideration.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Multicenter Study Clinical Trial Observational StudyEfficacy and safety of natalizumab in multiple sclerosis: interim observational programme results.
Clinical trials established the efficacy and safety of natalizumab. Data are needed over longer periods of time and in the clinical practice setting. ⋯ Interim TOP data confirm natalizumab's overall safety profile and the low relapse rate and stabilised disability levels in natalizumab-treated patients with RRMS in clinical practice.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialImmediate effect of spinal magnetic stimulation on camptocormia in Parkinson's disease.
Spinal cord stimulation is a potential therapeutic option for the treatment of Parkinson's disease (PD)-associated symptoms. Repetitive trans-spinal magnetic stimulation (rTSMS) is a non-invasive and safe alternative for stimulation of spinal pathways that has not been studied for therapeutic efficacy in PD. We assessed the benefits of rTSMS on camptocormia, an often treatment-resistant postural abnormality observed in PD patients. ⋯ UMIN Clinical Trials Registry: UMIN000011495.
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J. Neurol. Neurosurg. Psychiatr. · Nov 2014
Randomized Controlled TrialDegree of blood pressure reduction and recurrent stroke: the PROGRESS trial.
There is ongoing controversy regarding a 'J-curve' phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke. ⋯ The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease.