Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jan 2020
Development and assessment of the inter-rater and intra-rater reproducibility of a self-administration version of the ALSFRS-R.
The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) is widely applied to assess disease severity and progression in patients with motor neuron disease (MND). The objective of the study is to assess the inter-rater and intra-rater reproducibility, i.e., the inter-rater and intra-rater reliability and agreement, of a self-administration version of the ALSFRS-R for use in apps, online platforms, clinical care and trials. ⋯ The self-administration version of the ALSFRS-R demonstrates high reproducibility and can be used in apps and online portals for both individual comparisons, facilitating the management of clinical care and group comparisons in clinical trials.
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J. Neurol. Neurosurg. Psychiatr. · Jan 2020
Editorial CommentFGFR3 autoantibodies in sensory neuronopathy.
FGFR3 antibodies have been associated with sensory neuropathy, but many questions remain regarding their use in clinical practice.