Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Dec 2021
Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition.
To explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we studied a subsample of the Alzheimer's disease (AD) neuroimaging cohort with longitudinal blood peptide assessments. ⋯ P-tau and NfL behave differently within the same individuals over time and may therefore offer complementary diagnostic information.