Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
The heritability of amyloid burden in older adults: the Older Australian Twins Study.
To determine the proportional genetic contribution to the variability of cerebral β-amyloid load in older adults using the classic twin design. ⋯ Amyloid deposition, the hallmark early feature of Alzheimer's disease, is under moderate genetic influence, suggesting a major environmental contribution that may be amenable to intervention.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study.
To assess the association of regional grey matter atrophy with dementia risk in a general older Japanese population. ⋯ Our findings suggest that the total number of regions with grey matter atrophy among the medial temporal lobe, insula, hippocampus and amygdala is a significant predictor for developing dementia, especially AD, in the general older population.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
Clinical profile of fatal familial insomnia: phenotypic variation in 129 polymorphisms and geographical regions.
Elucidate the core clinical and genetic characteristics and identify the phenotypic variation between different regions and genotypes of fatal familial insomnia (FFI). ⋯ Insomnia, RPD and hypertension are representative key clinical presentations of FFI. Phenotypic variations in genotypes and geographic regions were documented. Prion protein gene 129 Met was considered to be a risk factor for FFI in the non-Asian population, and 129 polymorphisms could modify survival duration.