Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
Interstitial laser anterior capsulotomy for obsessive-compulsive disorder: lesion size and tractography correlate with outcome.
Anterior capsulotomy is a well-established treatment for refractory obsessive-compulsive disorder (OCD). MRI-guided laser interstitial thermal therapy (LITT) allows creation of large, sharply demarcated lesions with the safeguard of real-time imaging. ⋯ Laser anterior capsulotomy resulted in immediate, marked improvement in OCD symptom severity. Larger lesions permit greater disconnection of prefrontal-subcortical pathways involved in OCD. The importance of greater disconnection is presumably related to variation in ALIC structure and the complex role of the PFC in OCD.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
The heritability of amyloid burden in older adults: the Older Australian Twins Study.
To determine the proportional genetic contribution to the variability of cerebral β-amyloid load in older adults using the classic twin design. ⋯ Amyloid deposition, the hallmark early feature of Alzheimer's disease, is under moderate genetic influence, suggesting a major environmental contribution that may be amenable to intervention.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2022
Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study.
To assess the association of regional grey matter atrophy with dementia risk in a general older Japanese population. ⋯ Our findings suggest that the total number of regions with grey matter atrophy among the medial temporal lobe, insula, hippocampus and amygdala is a significant predictor for developing dementia, especially AD, in the general older population.