Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2021
Distinct latent profiles based on neurobehavioural, physical and psychosocial functioning of former National Football League (NFL) players: an NFL-LONG Study.
To identify subgroups of former National Football League (NFL) players using latent profile analysis (LPA) and examine their associations with total years of participation (TYP) and self-reported lifetime sport-related concussion history (SR-CHx). ⋯ Five distinct profiles of self-reported functioning were identified among former NFL players. Several comorbid factors (ie, medical/psychiatric diagnoses and psychosocial stressors) and SR-CHx were associated with greater neurobehavioural and psychosocial dysfunction.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2021
Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study.
We set out to determine which characteristics and outcomes of stroke are associated with COVID-19. ⋯ Our data suggest that COVID-19 may be an important modifier of the onset, characteristics and outcome of acute ischaemic stroke.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2021
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.
To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). ⋯ We report a standardised approach for the identification of candidate drugs for repurposing in the treatment of progressive MS.