Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2021
Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control study.
We set out to determine which characteristics and outcomes of stroke are associated with COVID-19. ⋯ Our data suggest that COVID-19 may be an important modifier of the onset, characteristics and outcome of acute ischaemic stroke.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2021
Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.
To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS). ⋯ We report a standardised approach for the identification of candidate drugs for repurposing in the treatment of progressive MS.
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To determine clinical manifestations, immunotherapy responsiveness and outcomes of glutamic acid decarboxylase-65 (GAD65) neurological autoimmunity. ⋯ High-titre GAD65 antibodies were suggestive of, but not pathognomonic for GAD65 neurological autoimmunity, which has discrete core and secondary manifestations. SPSD was most likely to respond to immunotherapy, while epilepsy was least immunotherapy responsive. Complete immunotherapy response was rare. Serum GAD65 antibody titre >500 nmol/L and cerebellar ataxia predicted poor outcome.