Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr.
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J. Neurol. Neurosurg. Psychiatr. · Aug 2020
Inclusion body myositis in patients with spinocerebellar ataxia types 3 and 6.
To describe the combination of spinocerebellar ataxia (SCA) types 3 and 6 and sporadic inclusion body myositis (IBM). ⋯ We report on five patients with concomitant SCA and IBM. Our cases may merely illustrate coincidental co-occurrence of IBM and SCA-3/SCA-6. However, the presence of SCA mutations could predispose to the development of IBM in some SCA patients, or, the presence of toxic aggregates and malfunctioning of cellular quality control processes in both diseases could indicate a convergence of disease mechanisms.