Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Mar 2020
Regional spreading of symptoms at diagnosis as a prognostic marker in amyotrophic lateral sclerosis: a population-based study.
The lack of prognostic biomarkers in patients with amyotrophic lateral sclerosis (ALS) induced researchers to develop clinical evaluation tools for stratification and survival prediction. We assessed the correlation between patterns of functional involvement, considered as a cumulative number of body regions involved, and overall survival in a population-based series of patients with ALS (PARALS). ⋯ The evaluation of NBRI, with the inclusion of initial respiratory/thoracic involvement and cognition, can be useful in many research fields, improving the stratification of patients. Our findings highlight the importance of the spatial spreading of functional impairment in the prediction of ALS outcome.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2020
Meta AnalysisSleep problems and risk of all-cause cognitive decline or dementia: an updated systematic review and meta-analysis.
To conduct an updated systematic review and meta-analysis of association between sleep and all-cause cognitive disorders. ⋯ Sleep management might serve as a promising target for dementia prevention.
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J. Neurol. Neurosurg. Psychiatr. · Mar 2020
Randomized Controlled Trial Multicenter StudyEffect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials.
To investigate the efficacy of rovatirelin, a thyrotropin-releasing hormone analogue, for ataxias in patients with spinocerebellar degeneration (SCD). ⋯ Rovatirelin is a potentially effective treatment option for SCD.