Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr. · Jun 2018
ReviewSystematic review of structural and functional brain alterations in psychosis of epilepsy.
This systematic review critically assesses structural and functional neuroimaging studies of psychosis of epilepsy (POE). We integrate findings from 18 studies of adults with POE to examine the prevailing view that there is a specific relationship between temporal lobe epilepsy (TLE) and POE, and that mesial temporal lobe pathology is a biomarker for POE. ⋯ Understanding POE as a disease of brain networks has important implications for neuroimaging research and clinical practice. Specifically, we suggest that future neuroimaging studies of POE target structural and functional networks, and that practitioners are vigilant for psychotic symptoms in all epilepsies, not just TLE.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2018
Biography Historical ArticleKinnier Wilson's puzzling features of amyotrophic lateral sclerosis.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2018
Randomized Controlled TrialRandomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor.
Trials for additional or alternative treatments for cervical dystonia (CD) are scarce since the introduction of botulinum neurotoxin (BoNT). We performed the first trial to investigate whether dystonic jerks/tremor in patients with CD respond to the selective serotonin reuptake inhibitor (SSRI) escitalopram. ⋯ In this innovative trial, no add-on effect of escitalopram for treatment of CD with jerks was found on motor or psychiatric symptoms. However, we also did not find a reason to withhold patients treatment with SSRIs for depression and anxiety, which are common in dystonia.
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J. Neurol. Neurosurg. Psychiatr. · Jun 2018
Randomized Controlled Trial Multicenter Study Comparative StudyIntrathecal baclofen therapy versus conventional medical management for severe poststroke spasticity: results from a multicentre, randomised, controlled, open-label trial (SISTERS).
Intrathecal baclofen (ITB) is a treatment option for patients with severe poststroke spasticity (PSS) who have not reached their therapy goal with other interventions. ⋯ These data support the use of ITB therapy as an alternative to CMM for treatment of generalised PSS in adults.