Journal of neurology, neurosurgery, and psychiatry
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2017
Comparative StudyPatterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
Imaging is recommended to support the clinical diagnoses of dementias, yet imaging research studies rarely have pathological confirmation of disease. This study aims to characterise patterns of brain volume loss in six primary pathologies compared with controls and to each other. ⋯ Pathologically distinct dementias exhibit characteristic patterns of regional volume loss compared with controls and other dementias. Voxelwise differences identified in these cohorts highlight imaging signatures that may aid in the differentiation of dementia subtypes during life. The results of this study are available for further examination via NeuroVault (http://neurovault.org/collections/ADHMHOPN/).
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2017
Observational StudyFactors affecting seizure outcome after epilepsy surgery: an observational series.
Surgical treatment can bring seizure remission in people with focal epilepsy but requires careful selection of candidates. ⋯ Readily identified clinical features and investigations are associated with reduced probability of good outcome and need consideration when planning presurgical evaluation.
-
J. Neurol. Neurosurg. Psychiatr. · Nov 2017
Structural MRI correlates of amyotrophic lateral sclerosis progression.
Amyotrophic lateral sclerosis (ALS) presents with varying degrees of brain degeneration that can extend beyond the corticospinal tract (CST). Furthermore, the clinical course and progression of ALS varies widely. Brain degeneration detected using structural MRI could reflect disease progression. ⋯ A more rapid disease progression and poorer functional decline were associated with greater involvement of the extra-motor cortex and basal ganglia, suggesting that the spatial extent of brain involvement can be an indicator of the progression in ALS.