Journal of neurology, neurosurgery, and psychiatry
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J. Neurol. Neurosurg. Psychiatr.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2017
Lymphocyte antigens targetable by monoclonal antibodies in non-systemic vasculitic neuropathy.
To identify the most relevant antigens for monoclonal antibodies in lymphocytic infiltrates in non-systemic vasculitic neuropathy (NSVN). ⋯ This is the first study in NSVN that identifies antigens expressed by pathogenic lymphocytes, which are potential targets for future monoclonal antibody treatment. Our data suggest that NSVN is amenable to monoclonal antibodies and, moreover, that targeting CD52 may be particularly promising. Our results strongly warrant future clinical trials in NSVN with monoclonal antibodies.
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J. Neurol. Neurosurg. Psychiatr. · Sep 2017
Editorial Biography Historical ArticleSir Henry Head FRS (1861-1940): a life in science and society.